大连美仑生物技术有限公司

Apoptosis Bcl-2 Bcl-6 Caspase Ferroptosis Mdm2 p53 RIP kinase Survivin TNF-alpha Cuproptosis IAP Metabolic Enzyme/Protease PDHK ROS Kinase Phosphatase MDM-2/p53 Kinesin PKC HSP Autophagy TNF Receptor FKBP Bcl-2 Family Pyroptosis DAPK PKD EBV Glutathione Peroxidase Transferrin Receptor c-Myc Necroptosis ASK1 Thymidylate Synthase

Autophagy

Autophagy LRRK2 Estrogen/progestogen PINK1/Parkin Dynamin Anti-infection Oxidative Phosphorylation Akt AMPK JAK Toll-like Receptor (TLR) ULK p62 Atg8/LC3 Atg7 Atg4 AUTACs

Epigenetics

DNA Methyltransferase DNMT Epigenetic Reader Domain Histone Acetyltransferase Histone demethylases Histone Methyltransferase PKC AMPK HDAC JAK MicroRNA Protein Arginine Deiminase Phosphodiesterase (PDE)

GPCR/G Protein

Adenosine Receptor Angiotensin Receptor Cannabinoid Receptor CaSR E1 Activating CRFR E2 conjugating E3 Ligase Endothelin Receptor GHSR Glucagon Receptor GLP-1R GPCR19(TGR5) GPR GPR119 GPR40(FFAR1) Imidazoline Receptor Leukotriene Receptor LPA Receptor OX Receptor Protease-activated Receptor Rac Prostaglandin Receptor Oxytocin Receptor Ras Rho S1P Receptor Sigma Receptor 5-HT Receptor Neurokinin Receptor mAChR GCGR LPL Receptor Dopamine Receptor Guanylate Cyclase Histamine Receptor CXCR CCR GPR35 P2Y Receptor Opioid Receptor GPR68 mGluR Formyl Peptide Receptor (FPR) Platelet-activating Factor Rec GnRH Receptor Protease Activated Receptor (P Vasopressin Receptor Chemerin Receptor Melatonin Receptor MCHR1 (GPR24) Orexin Receptor (OX Receptor) RGS Protein CGRP Receptor Free Fatty Acid Receptor

Immunology/Inflammation

AhR CCR COX Complement 5(C5) CXCR Histamine Receptor IL Receptor Immunology IL-5 NOD1 IL-12 PD-1 IL-17 PDL-1 reactive oxygen species (ROS) NLRP3 TLR STING Toll-like Receptor (TLR) Bcr-Abl Salt-inducible Kinase (SIK) Glucocorticoid Receptor IRAK SphK Interleukin Related PGE synthase Macrophage migration inhibitor Complement System MyD88 FLAP Thrombopoietin Receptor Arginase NO Synthase AP-1 Nuclear Factor of activated T IFNAR CD276/B7-H3 CD3 CD38 CD28 CD22 CD20 CD19 Aryl Hydrocarbon Receptor PD-1/PD-L1 NOD-like Receptor (NLR) Mesothelin Mucin NTPDase PSMA SOD DOCK CD74 CD6 CD73 CTLA-4 CX3CR1 Cyclic GMP-AMP Synthase FAP Galectin Cyclophilin P-selectin CD2 CD47 Tim3 TROP2 Glycoprotein VI Kallikrein LAG-3 VAP-1 BCL6

Integrin

JAK-STAT/IL6

JAK STAT IL-6 Pim EGFR

MAPK

ErbB2 ERK JNK MEK p38 MAPK Mixed Lineage Kinase Raf

Membrane Transporter/Ion Chann

Amino acid transporter antagon ATPase Calcium Channel CFTR Chloride channel CRM1 GABA Receptor GluR iGluR NMDAR P-gp Potassium Channel Proton Pump SGLT Sodium Channel TRPV P-glycoprotein Na+/K+ ATPase Piezo Channel Fat Mass and Obesity-associate TRP Channel BCRP nAChR CRAC Channel Apical Sodium-Dependent Bile A P2X Receptor Monocarboxylate Transporter Na+/HCO3- Cotransporter GlyT OAT NKCC Monoamine Transporter HCN Channel EAAT Ferroportin GLUT Na+/H+ Exchanger (NHE) Na+/Ca2+ Exchanger FATP ATP Synthase ASCT VDAC Urea Transporter URAT1 Aquaporin Calmodulin

Metabolic Enzyme/Protease

5-alpha Reductase Aminopeptidase ATP-citrate lyase in Carbonic Anhydrase CETP DGAT DPP-4 Factor Xa FOX FXR Glucokinase(GK) GSNOR HCV Protease HIF HMG-CoA Reductase HSP IDO Lactate Dehydrogenase Integrase MMP NAMPT P450 PAI-1 PDE PGC-1α Phospholipase Procollagen C Protein Proteases PKM Proteasome RAR/RXR Retinoid Receptor Serine Protease Thrombin Transferase Xanthine Oxidase p38-MAPK Stearoyl-CoA Desaturase (SCD) Mitochondrial Metabolism (MPC) Tyrosinase Endogenous Metabolite Phosphatase Pyruvate Kinase PDI Phosphodiesterase (PDE) HIF/HIF Prolyl-Hydroxylase Hexokinase Ser/Thr Protease Carboxylesterase Cathepsin Cytochrome P450 Drug Metabolite E1/E2/E3 Enzyme Angiotensin-converting Enzyme HMG-CoA Reductase (HMGCR) Aldose Reductase Oxidative Phosphorylation NADPH Oxidase Lipoxygenase DAGL MAGL MALT1 Adenosine Kinase COMT Glutathione S-transferase Adenosine Deaminase Acyltransferase Enolase Aldehyde Dehydrogenase (ALDH) Farnesyl Transferase Glucosidase PDHK Fatty Acid Synthase (FASN) Dipeptidyl Peptidase Methylenetetrahydrofolate Dehy Dihydroorotate Dehydrogenase Renin FAAH SGK Dopamine β-hydroxylase HIV Integrase Adiponectin Receptor ROR LXR Mineralocorticoid Receptor REV-ERB Amine N-methyltransferase

Neuronal Signaling

5-HT Receptor AChR BACE Beta Amyloid Beta-secretase CaMK CGRP Receptor Dopamine Receptor FAAH Gamma-secretase GlyT iGluR MAO mAChR Opioid Receptor Serotonin Transporter Legumain γ-secretase Notch Monoamine Oxidase Trk Receptor Cholinesterase (ChE) Imidazoline Receptor Amyloid-β Dopamine Transporter Sigma Receptor Glucosylceramide Synthase (GCS

NF-κB

NF-κB Nrf2 IκB/IKK Reactive Oxygen Species Keap1-Nrf2 IKK RANKL/RANK

Others

Androgen Receptor Aromatase CD20 CD52 c-Myc CPT1 c-RET CTLA-4 Decarboxylase Dehydrogenase FPR GLUT Glutaminase HIV ProteaseAnti-infection HSP90 Hydroxylase IAP IgE IRE1 LDL Lipase Lipoxygenase Lysyl Hydroxylase MT Receptor NADPH oxidase others P2 Receptor PAFR PCSK9 RAAS RANK Ligand Reverse Transcriptase S6 Kinase Thioredoxin Tie-2 SARM Vasopressin Receptor VDA Vitamin D Related CDA TrxR PDE IDO

PI3K/Akt/mTOR

Akt MELK mTOR GSK-3 PDK-1 PI3K PIKfyve PTEN RSK AMPK PI4K PIN1

Protein Tyrosine Kinase/PTK

ACK ALK Axl Bcr-Abl BTK cAMP(PKA) c-Kit c-Met CSF-1R DYRK EGFR Ephrin receptor FAK FGFR FLT3 HER2 IGF-1R MET Insulin Receptor PDGFR PKA ROS Src Syk Trk receptor VEGFR

Stem Cell /Wnt

c-Jun Hedgehog/Smoothened Hippo pathway Met stemness kinase OCT Wnt/β-catenin Adenylate Cyclase YAP PKA TGF-beta/Smad Gli Wnt sFRP-1 Smo Organoid Hedgehog Porcupine PKG Hippo (MST) Oct3/4 β-catenin BMI1

TGF-beta/Smad

TGF-beta/Smad TGF-β Receptor PKC PKA

Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK CD38 Chk DHFR DNA alkylator DNA-PK DNA/RNA Synthesis DUB Dynamin HDAC HSP Kinesin Microtubule Associated p97 MTH1 PAK PERK PLK PPAR PARP ROCK Sirtuin RAD51 Telomerase TOPK Topoisomerase Wee1 Deubiquitinase NEKs OGG Polo-like Kinase (PLK) Microtubule/Tubulin Mps1 MASTL Haspin Kinase SRPK DNA Alkylator/Crosslinker ATF6 Checkpoint Kinase (Chk) G-quadruplex Nucleoside Antimetabolite/Anal Eukaryotic Initiation Factor ( CRISPR/Cas9 IRE1 MARK Epoxide Hydrolase

Protein Tyrosine Kinase/RTK

TAM Receptor ROS Kinase JAK Src VEGFR c-Met Syk ALK FAK IGF-1R FLT3 c-Met/HGFR PDGFR Bcr-Abl c-Fms Ephrin receptor FLT3 BTK Itk Anaplastic lymphoma kinase (AL Ack1 RET c-Kit FGFR EGFR Insulin Receptor Discoidin Domain Receptor BRK BMX Kinase SHP2 DYRK Tie Pyk2 GDNF Receptor

Epigenetics Histone

Methyltransferase

Anti-infection

HSV Flavivirus others Fungal Parasite HBV Bacterial Dengue virus HIV Filovirus Antibiotic VSV SARS-CoV Beta-lactamase HCV CMV Reverse Transcriptase Influenza Virus Arenavirus HIV Protease

MAPK/ERK Pathway

ERK p38 MAPK MEK MAP3K Ribosomal S6 Kinase (RSK) Raf JNK MAP4K KLF Mixed Lineage Kinase MNK

Vitamin D Related/Nuclear Rece

Estrogen Receptor/ERR Progesterone Receptor VD/VDR Androgen Receptor Thyroid Hormone Receptor Nuclear Hormone Receptor 4A/NR Constitutive Androstane Recept

Cytoskeleton

MARCKS Integrin Gap Junction Protein Myosin Polo-like Kinase (PLK) Annexin A Dynamin Arp2/3 Complex

Antibodydrug Conjugate/ADC Rel

ADC Cytotoxin Antibody-Drug Conjugates (ADCs Drug-Linker Conjugates for ADC

PROTAC

Molecular Glues PROTACs Ligands for Target Protein for PROTAC Linkers Ligands for E3 Ligase E3 Ligase Ligand-Linker Conjug PROTAC-Linker Conjugates for P Target Protein Ligand-Linker C SNIPERs LYTACs AUTOTACs

通用试剂类

氨基酸

氨基酸犬尿氨酸系列

胆酸系列

蛋白及衍生物

合成多肽

核酸及其衍生物

抗生素及抗病毒

抗生素及抗病毒抗真菌抗生素抗细菌抗生素抗肿瘤抗生素抗病毒化合物

酶辅酶

染色剂指示剂

生物缓冲剂

碳水化合物

碳水化合物多糖寡糖去垢剂

通用试剂

微生物检测

微生物培养基

维生素

显色及标记试剂

植物生长激素

其他生化试剂

其他生化试剂表面活性剂无机盐

还原剂

蛋白修饰

交联剂

表面活性剂/去垢剂

非离子表活剂/去垢剂阴离子表活剂/去垢剂阳离子表活剂/去垢剂

生物耗材

吸头类

常规吸头滤芯吸头（PCR用）

PCR类

离心管类

常规离心管

细胞培养类

细胞培养板细胞培养皿细胞冻存培养瓶

液体处理类

移液管

体外诊断

核心原料

亲和素

重组蛋白

IgG-Fc

植物研究相关

植物激素

赤霉素类(GA) 细胞分裂素(CTK) 油菜素甾醇(BR) 其他植物激素脱落酸（ABA）乙烯(ETH)

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(S)-(+)-脱落酸(95%)

总货号: MB0164

货号	规格	发货时间
MB0164-1	100MG/只 [￥80.00] :￥80.00	现货
MB0164-2	500MG/只 [￥260.00] :￥260.00	现货
MB0164-3	1G/只 [￥380.00] :￥380.00	现货
MB0164-4	5G/只 [￥980.00] :￥980.00	现货

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相关论文

分子式：C₁₅H₂₀O₄分子量：264.32

简介：脱落酸（abscisic acid，ABA）是一种植物激素，是植物体内由倍半萜结构合成的一种生长调节剂。其在植物胚胎发育、种子休眠、果实成熟、叶片脱落、气孔运动和抵抗逆境胁迫等多方面具有重要的生理功能。脱落酸不仅存在于植物中，也存在于哺乳动物体内，可由人类细胞(功能性干细胞、免疫反应细胞、心血管细胞群和胰腺细胞等)产生和释放，介导一系列生理反应，如参与炎症、免疫、血糖及神经的调节中。

别名：(+)-Abscisic acid (ABA), (S)-(+)-Abscisic acid, Abscisic acid, ABA, (+)-脱落酸

物理性状及指标：
外观：……………………白色至淡黄色粉末

溶解性：…………………DMSO：20mg/mL；乙醇：20mg/mL

熔点：……………………163℃

比旋光度 [α]D：……… 410° (C=0.2,EtOH)
碳含量：…………………68.17 %

氢含量：…………………7.63 %

储存条件：2-8℃，避光防潮密闭干燥

运输条件：常温运输

产品用途：科研试剂，广泛应用于分子生物学，药理学等科研方面，严禁用于人体。

1. 调控植物的抗逆境胁迫：ABA 通过促进株体休眠、关闭气孔减小蒸腾、激活抗性系统、诱导胁迫相关基因的表达等方式，促进植物对胁迫环境的适应；

2. 调控根系构型：逆境胁迫研究中ABA抑制根系生长，但在干旱条件下ABA大量积累，促进根系生长；

3. 诱导植物此生代谢产物的积累：ABA能够选择地激活植物特定类型刺激代谢产物的生物合成；

4. 调节血糖：ABA 通过与受体 LANCL2 结合，刺激脂肪细胞与肌细胞对葡萄糖的摄取与利用，增加能量消耗控制葡萄糖的代谢，从而改善葡萄糖耐量，降低空腹血糖水平；

5. 免疫调节与抗炎作用：ABA 作为一种内源性信号分子，在哺乳动物体内发挥免疫调节与抗炎作用。如在小鼠实验中，对DSS小鼠模型有预防与改善作用，通过减少白细胞进入，下调细胞粘附分子的表达，增加CD4+T细胞调节蛋白的表达来减轻肠道验证；

6. 神经细胞调节作用：ABA 在大鼠、猪大脑中均有表达，其能抑制神经炎症、促进神经发生、改善突触可塑性，对学习记忆具有十分重要的意义。

生物活性：（来源于公开文献，仅供参考）

靶点

微生物代谢产物；人内源性代谢物

体外研究

1. 在拟南芥细胞培养物中，ABA；10 μM) 同时诱导培养基快速碱化和质膜去极化^[⁸^]。

2. ABA (10 μM) 增加拟南芥细胞悬浮液细胞质中的 Ca2+。ABA 不会直接抑制质子泵送，而是通过增加细胞溶质 Ca2+ 来抑制质子泵送^[⁸^]。

3. 羊毛硫氨酸合成酶C-like 2 (LANCL2) 是 ABA 的天然受体。在生物体水平和离体特定肌肉细胞中，ABA 增加线粒体中的葡萄糖和脂肪酸代谢，增加糖原合成，独立于胰岛素激活 PI3K并促进 GLUT4 易位至细胞膜^[⁹^]。

体内研究

ABA (口服；0.125 μg/kg/天；持续 12 周) 改善血糖控制^[⁹^]。

ABA (口服；0.125 μg/kg/天；持续 12 周) 导致 DIO 模型中 TNF、MCP-1 和 IL-6 水平显著降低。Abscisic acid 可增加骨骼肌的代谢活性^[⁹^]。

储液配制

	1 mg	5 mg	10 mg
1 mM	3.7833 mL	18.9165 mL	37.8329 mL
5 mM	0.7567 mL	3.7833 mL	7.5666 mL
10 mM	0.3783 mL	1.8916 mL	3.7833 mL

【注意】

●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。

●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。

参考文献：

[1] Lievens L, Pollier J, Goossens A, Beyaert R, Staal J. Abscisic Acid as Pathogen Effector and Immune Regulator. Front Plant Sci. 2017 Apr 19;8:587.

[2] Smet I D, Zhang H, D Inzé, T Beeckman. A novel role for abscisic acid emerges from underground. Trends in Plant Science, 2006, 11(9):434-439.

[3] Růzicka Kamil, Ljung Karin, Vanneste Steffen, Podhorská Radka, Beeckman Tom, Friml Jirí, Benková Eva. Ethylene regulates root growth through effects on auxin biosynthesis and transport-dependent auxin distribution. The Plant cell, 2007, 19(7):2197-2212.

[4] Sessegolo, C., Cruaud, C., Da Silva, C. et al. Transcriptome profiling of mouse samples using nanopore sequencing of cDNA and RNA molecules. Sci Rep 9, 14908 (2019).

[5] Sturla, L, Mannino, E, Scarfì, S, et al., Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo, Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 2017. 1862(2), 131-144.

[6] Leber, A, Hontecillas, R, Tubau-Juni, N, et al., Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle, Sci. Rep. 2020. 10(1), 10463.

[7] Sanchez-Sarasua, S, Moustafa, S, Garcia-Aviles, A, et al., The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation, Nutr. Metab. 2016. 13(20), 73.

[8]. Mathias Brault, et al. Plasma membrane depolarization induced by abscisic acid in Arabidopsis suspension cells involves reduction of proton pumping in addition to anion channel activation, which are both Ca2+ dependent. Plant Physiol. 2004 May;135(1):231-43.

[9]. Andrew Leber, et al. Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle. Sci Rep. 2020 Jun 26;10(1):10463.

我司所售出产品仅供于科研研究用途（非临床科研研究），每次销售产品行为都适用于我司网上所列明的通用销售条款。

CAS 号：21293-29-8

英文名字：(+)-Abscisic acid (ABA)

质量标准：HPLC≥95%,BR

摩尔浓度计算器（本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系）

摩尔浓度计算公式：质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

质量（g）

浓度 (mol/L)

体积 (L)

分子量 (g/mol)