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Flumequine
总货号: MB5439
货号 规格 库存 发货时间
10mg [¥300.00] :¥300.00
15
现货
50mg [¥1200.00] :¥1200.00
15
现货
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摩尔浓度计算器
相关论文
氟甲喹
分子式:C14H12FNO3    分子量:261.25
 
 
 

产品描述

Flumequine是一种人工合成的抗生素,在旋转酶/拓扑异构酶水平影响哺乳动物细胞染色体和DNA解旋。

靶点

Topoisomerase II

         

IC50

15 μM

         

体外研究

Flumequine inhibits eukaryotic topoisomerase II, which is responsible for the double-strand DNA breakage reaction as well as bacterial gyrase, inhibitory effects of FL on topoisomerase II are high relative to the influence on bacterial gyrase. Flumequine has minimum inhibitory concentration (MIC) ranging from 0.06 μg/mL to 32 μg/mL in 12 clinical A. salmonicida isolates. Flumequine enhibits high E(max) values of 16 for the most resistant isolates, which indicates an important contribution of efflux to the resistance phenotype. Flumequine accumulation experiments confirmes that high E(max) values are associated with a much lower level of accumulation.

体内研究

Flumequine (4000 ppm, oral diet) induces dose-dependent DNA damage in the stomach, colon, and urinary bladder of adult mice at 3 hours but not at 24 hours after its administration.Flumequine shows the bioavailability of 44.7% following oral administration of medicated feed in Atlantic salmon. Flumequine results in the volumes of distribution at steady state of 3.5 L/kg, elimination half-life (t 1/2) of 22.8 hours and area under plasma drug concentration-time curve (AUC) of 140 μg×hours/mL following intravenous administration in Atlantic salmon. Flumequine (100 mg/L) reduces the mean length of root, hypocotyle, cotyledon and the mean number of secondary roots in aquatic weed Lythrum salicaria L. Flumequine (10 mg/kg, oral) results in the volumes of distribution at steady-state (Vss) of 2.41 L/kg (cod) and 2.15 L/kg (wrasse) following intravenous administration. Total body clearances (Cl) are 0.024 L/h.kg (cod) and 0.14 L/h.kg (wrasse) and the elimination half-lives (t1/2 λ z) are calculated to be 75 hours (cod) and 31 hours (wrasse) after Flumequine (10 mg/kg, oral) administration. The oral bioavailabilities (F) are calculated to be 65% (cod) and 41% (wrasse) following oral administration of Flumequine.

溶解性

DMSO 3 mg/mL,水 <1 mg/mL,乙醇 <1 mg/mL

稳定性

2 -20°C粉状,6-80°C溶于DMSO

特征

           

我司所售出产品仅供于科研研究用途(非临床科研研究),每次销售产品行为都适用于我司网上所列明的通用销售条款。

CAS 号:42835-25-6
英文名字:氟甲喹
质量标准:>98%,BR,进分
分子式:C14H12FNO3 
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