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 Manidipine 2HCl
Manidipine 2HCl
Manidipine 2HCl
商品货号:CL-11011
CAS 号:89226-75-5
英文名字: Manidipine 2HCl
质量标准:>98%
分子式:C35H38N4O6.2HCl
  • 包装规格:
    规格 库存 发货时间
    25mg [¥640.00]15 现货,一周内发货
    50mg [¥900.00]15 现货,一周内发货
    200mg [¥2710.00]15 现货,一周内发货
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    商品信息

    质检证书(coa)

    说明书下载

     Manidipine 2HCl

    分子式C35H38N4O6.2HCl   分子量683.62

     

    产品描述

    ManidipineHCl  ManidipineHCl盐形式calcium channel阻断剂,IC502.6 nM, 临床上常用于抗高血压。

    靶点

    Ca2+ current

             

    IC50

    2.6 nM

             

    体外研究

    At a holding potential of 37 mV, Manidipine decreases the Ca2+ current at concentrations above 0.1 nM, and abolishes it at 100 nM.Manidipine concentration-dependently inhibits the calcium concentration response curves. Manidipine inhibits coronay artery and renal artery with pIC50 of 9.3 nM and 9.1 nM, respectively.Manidipine partly inhibits sympathetic nerve activity and suppresses the mean arterial pressure response to infused norepinephrine. Manidipine also inhibits aldosterone secretion. Manidipine increases in both urinary calcium and uric acid.In addition, Manidipine, at nanomolar concentrations, is efficacious in modulating gene transcriptions that are involved in proinflammatory changes of mesangial cells.

    体内研究

    Manidipine (3 mg/kg and 10 mg/kg, p.o.) dose-dependently decreases systolic blood pressure in the three types of hypertensive rats. At the dose of 10 mg/kg, Manidipine decreases the blood pressure to the normotensive level between 1 hour and 3 hours after Manidipine is administered; the antihypertensive effect lasted for at least 8 hours.When Manidipine is administered at 10 μg/kg, the hypotensive action is markedly augmented.Manidipine potently inhibits the Ca inward current, When the potential is at -60 mV. Manidipine consistently inhibits the Ca current evoked by depolarization to 0 mV. However, a low concentration of Manidipine (1-3 nM) enhances the Ca current evoked by the depolarizing pulse of -20 mV, when the membrane potential is held at -80 mV. Inhibition of the Ca current induced by Manidipine develops slowly and over 10 minutes is required to reach the maximum inhibition.

    溶解性

    DMSO 21 mg/mL,水 <1 mg/mL,乙醇 <1 mg/mL

    稳定性

    2 -20°C粉状,6-80°C溶于DMSO

    特征

             

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