WB (western blot)系列产品开学促销【详情
公告:关于美仑生物赠送预制胶发货时间推迟的通知详情
400-659-9898
 
400-659-9898 登陆立即注册账户余额:|我的订单 |积分兑换
   
购物车 0 件
专业顾问
  免费热线:400-659-9898
  我们将竭诚为您服务
 
推荐产品
 
牛血清白蛋白(BSA);牛血清白蛋白组分五
Meilunbio®飞克特超敏ECL发光液(100ML)
细胞增殖及毒性检测试剂盒(CCK-8),100T增强型
水溶性两性霉素B(Meilunbio)
紫杉醇
盐酸多柔比星/盐酸阿霉素
 
 
当前位置: 首页 > 信号通路研究 > DNA Methyltransferas > SGI-110
SGI-110
SGI-110
SGI-110
商品货号:CL-10557
CAS 号:929901-49-5
英文名字:SGI110
质量标准:>98%,有效的DNA methylation抑制剂
分子式:C18H24N9O10P
会员尊享价:

商品信息

质检证书(coa)

说明书下载

 SGI110

分子式:C18H24N9O10P   分子量557.41

 

产品描述

SGI-110 (S-110)是稳定的,有效的DNA methylation抑制剂, SGI-110通过磷酸化激活,且渗透进DNA,则抑制DNMT1

靶点

           

IC50

           

体外研究

SGI-110 is a 5-aza-2’-deoxycytidine-containing demethylating dinucleotide, which works via a mechanism similar to that of 5-aza-CdR after incorporation of its aza-moiety into DNA. However, SGI-110 is well protected from deamination by cytidine deaminase. SGI-110 (1 μM) induces significantly decrease in the level of methylation in both T24 and HCT116 cells. SGI-110 is able to induce robust p16 expression. SGI-110 (1 μM) causes depletion of extractable DNMT1 in cells. SGI-110 decreases the plating efficiency of T24 bladder carcinoma cells in a dose-dependent manner, with no colonies forming at 10 μM concentration, which is quite similar to 5-aza-CdR in T24 cells. SGI-110 shows immunomodulatory activity in vitro. SGI-110 (1 μM) induces/up-regulates the expression of several cancer/testis antigens (CTA) (i.e., MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A10, GAGE 1-2, GAGE 1-6, NY-ESO-1, and SSX 1-5) in cancer cell lines (cutaneous melanoma, mesothelioma, renal cell carcinoma, and sarcoma cells), both at mRNA and at protein levels. SGI-110 also up-regulates the expression of HLA class I antigens and of ICAM-1, resulting in an improved recognition of cancer cells by gp100-specific CTL.

体内研究

SGI-110 is as effective as 5-Aza-CdR, but is better tolerated in mice. SGI-110 (10 mg/kg) displays potent activity on inducing p16 expression, reducing DNA methylation at the p16 promoter region, and retarding tumor growth in human xenograft. SGI-110 is effective by both i.p. and s.c. deliveries.

溶解性

 

稳定性

2 -20°C粉状,6-80°C溶于DMSO

特征

           

我司所售出产品仅供于科研研究用途,每次销售产品行为都适用于我司网上所列明的通用销售条款。

http://www.meilune.com/article.php?id=374

请输入货号:


请输入批号:
请输入货号:
新手指引
会员体系
购物流程
服务协议
支付方式
线下支付
在线支付
配送方式
配送范围
配送费用
配送时间
售后服务
质量异议
产品应用
退换货流程
帮助中心
用户注册
找回密码
关于我们
公司简介 | 快递查询 | 联系我们 | 官方Blog | 生意宝 | 爱化学 | ChemicalBook
电话:0411-66771943, 66771942, 82593920
传真:0411-82593613, 66771945, | 电子邮件:sales@meilune.com
技术咨询及投诉:tech@meilune.com
所有的产品和服务只应用于科学研究,不得用于人体,我们不提供产品和服务给任何个人
© 2005-2019 大连美仑生物技术有限公司 版权所有,并保留所有权利。 ICP备案证书号:辽ICP备10016015号-4
扫描关注美仑生物试剂专家,咨询订购更方便!   首单有礼!!!